Заглавие | Statistical properties of the least squares estimator of maximum excreted drug amount |
Вид публикация | Journal Article |
Година на публикуване | 1996 |
Автори | Prodanova K |
Списание | Annuaire de l’Université de Sofia “St. Kliment Ohridski”. Faculté de Mathématiques et Informatique |
Том | 88 |
Issue | Livre 3 |
Pagination | 347-360 |
Резюме | Inaccuracy in estimation of the maximum excreted drug amount ($U^{\infty}$) is the main cause of errors in determination of some pharmacokinetic parameters of drugs. Usually, one estimates $U^{\infty}$ using observed values of the cummulative excretion ($U(t)$). This paper uses a new stochastic model to obtain the least squares estimator of $U^{\infty}$. The advantages of the model are that it is applicable for any drug, whose pharmacokinetics may be formalized with a linear $n$-compartment model ($n=1,2,3,...$) with or without phase of absorption and it may be used when the measurements for $U(t)$ are non-equidistant. |
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88-347-360.pdf | 263.12 KB |